1. (A) Example time series for data and simulation.
(A) Example time series for data and simulation. One fit in liver (left) and one fit in the SCN (right) are shown. Expression levels are normalized to the mean values. The liver fit has a score of 0.01 and involves the Bmal1–Rev-erb-α, repressilator, and Cry1 loops, whereas the SCN fit scores 3.36 and involves the Bmal1–Rev-erb-α, Per2, and Cry1 loops. Note the smaller amplitudes and the early Cry1 phase in the SCN. (B) Workflow of the analysis. Multiple optimized parameter sets are obtained from each tissue-specific data set. Then essential loops are identified in the respective models.
J Patrick Pett et al. LSA 2018;1:e
© 2018 Pett et al.