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Supplementary Figure S3
Supplementary Figure S3. Association of level of lymphocyte infiltration with OS in the combined (left panel), Uppsala-I (mid panel) and Uppsala-II (right panel) cohort illustrated by Kaplan-Meier plots. A, IHC score 0-1 vs. 2-3; B, IHC score 0‑2 vs. 3; C, IHC score 0 vs. 1 vs. 2 vs. 3; D, Combinations of CD8 & IGKC (left panel), CD8 & Ki67 (mid panel), and IGKC & Ki67 (right panel). P values from the log-rank test are given in the plots. S3A Combined Uppsala-I Uppsala-II CD3 0-1 CD3 2-3 P = 0.008 P = 0.028 P = 0.165 CD8 0-1 CD8 2-3 P = 0.004 P = 0.008 P = 0.188 CD4 0-1 CD4 2-3 P = 0.005 P = 0.025 P = 0.101 FOXP3 0-1 FOXP3 2-3 P = 0.060 P = 0.073 P = 0.422 CD20 0-1 CD20 2-3 P = 0.042 P = 0.201 P = 0.082
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S3A, continued Combined Uppsala-I Uppsala-II CD79A 0-2 CD79A 3
IGKC 0-2 IGKC 3 P = 0.012 P = 0.171 P = 0.026
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S3B Combined Uppsala-I Uppsala-II CD3 0-2 CD3 3 P = 0.014 P = 0.076
FOXP3 0-2 FOXP3 3 P = 0.050 P = 0.023 P = 0.714 CD20 0-2 CD20 3 P = 0.941 P = 0.485 P = 0.331 CD79A 0-2 CD79A 3 P = 0.003 P = 0.175 P = 0.006 IGKC 0-2 IGKC 3 P = 0.012 P = 0.171 P = 0.026
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S3C Combined Uppsala-I Uppsala-II CD3 0 CD3 1 CD3 2 CD3 3 P = 0.021
FOXP3 0 FOXP3 1 FOXP3 2 FOXP3 3 P = 0.190 P = 0.137 P = 0.856 CD20 0 CD20 1 CD20 2 CD20 3 P = 0.097 P = 0.179 P = 0.358 CD79A 0 CD79A 1 CD79A 2 CD79A 3 P = 0.012 P = 0.404 P = 0.033 IGKC 0 IGKC 1 IGKC 2 IGKC 3 P = 0.003 P = 0.002 P = 0.136
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S3D Combined: CD8 & IGKC Combined: CD8 & Ki67 Combined: IGKC & Ki67
P = 0.001 P < 0.001 P < 0.001 CD8-high, IGKC-high CD8-low, IGKC-high CD8-high, IGKC-low CD8-low, IGKC-low CD8-high, Ki67-high IGKC-high, Ki67-high CD8-low, Ki67-high IGKC-low, Ki67-high CD8-high, Ki67-low IGKC-high, Ki67-low CD8-low, Ki67-low IGKC-low, Ki67-low CD8 & IGKC: low 0-1; high 2-3 CD8: low 0-1; high 2-3 IGKC: low 0-1; high 2-3 P = 0.002 P < 0.001 P < 0.001 CD8-high, IGKC-high CD8-low, IGKC-high CD8-high, IGKC-low CD8-low, IGKC-low CD8-high, Ki67-high IGKC-high, Ki67-high CD8-low, Ki67-high IGKC-low, Ki67-high CD8-high, Ki67-low IGKC-high, Ki67-low CD8-low, Ki67-low IGKC-low, Ki67-low CD8 & IGKC: low 0-2; high 3 CD8: low 0-2; high 3 IGKC: low 0-2; high 3
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