1. Nat. Rev. Endocrinol. doi:10.1038/nrendo.2017.47
Figure 4 TRH stimulation test in controls and in patients with hypothalamic hypothyroidism
Figure 4 | TRH stimulation test in controls and in patients with hypothalamic hypothyroidism. Net increments of serum levels of TSH, free T4 and free T3 after a TSH-releasing hormone (TRH) stimulation test in patients with central hypothyroidism of hypothalamic origin and controls matched for age and sex. Note the exaggerated TSH response and the significantly smaller increase in free T4 and free T3 in hypothalamic hypothyroidism. These results provide an indirect estimate of the poor bioactivity of TSH molecules secreted in these conditions. the asterisks indicate a highly significant difference (P < 0.001) between patients and controls. Adapted from Persani, L. & Beck-Peccoz, P. in Werner and Ingbar's the Thyroid: a Fundamental and Clinical Text 10th edn (eds Braverman L. E. & Cooper D.) 560–568. (Lippincott Williams, Wilkins, 2012).
Adapted from Persani, L. & Beck-Peccoz, P. in Werner and Ingbar’s the Thyroid: a Fundamental
and Clinical Text 10th edn (eds Braverman L. E. & Cooper D.) 560–568. (Lippincott Williams, Wilkins, 2012).
Beck-Peccoz, P. et al. (2017) Central hypothyroidism — a neglected thyroid disorder
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