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Cellular effects of TFEB that might be of therapeutic benefit in lysosomal storage disorders Cellular effects of TFEB that might be of therapeutic benefit.

Published byΆνεμονη Μανωλάς Modified over 5 years ago

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Presentation on theme: "Cellular effects of TFEB that might be of therapeutic benefit in lysosomal storage disorders Cellular effects of TFEB that might be of therapeutic benefit."— Presentation transcript:

1 Cellular effects of TFEB that might be of therapeutic benefit in lysosomal storage disorders
Cellular effects of TFEB that might be of therapeutic benefit in lysosomal storage disorders Lysosomal Ca2+ efflux through TRPML1 activates the Ca2+-dependent phosphatase calcineurin, which mediates dephosphorylation-dependent nuclear translocation of TFEB. Nuclear TFEB up-regulates the transcription of genes involved in lysosome biogenesis and autophagy, thereby enhancing autophagic flux. In addition, Ca2+ efflux from peripheral lysosomes promotes lysosomal exocytosis and the secretion of non-degraded materials. Elena Seranova et al. Essays Biochem. 2017;61: ©2017 by Portland Press Ltd

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