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Volume 78, Issue 7, Pages (October 2010)

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Presentation on theme: "Volume 78, Issue 7, Pages (October 2010)"— Presentation transcript:

1 Volume 78, Issue 7, Pages 679-685 (October 2010)
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease  Mahmut I. Yilmaz, Alper Sonmez, Mutlu Saglam, Halil Yaman, Selim Kilic, Erkan Demirkaya, Tayfun Eyileten, Kayser Caglar, Yusuf Oguz, Abdulgaffar Vural, Mujdat Yenicesu, Carmine Zoccali  Kidney International  Volume 78, Issue 7, Pages (October 2010) DOI: /ki Copyright © 2010 International Society of Nephrology Terms and Conditions

2 Figure 1 The association between FGF-23 and endothelial dysfunction. Relationship between fibroblast growth factor (FGF)-23 and flow-mediated vasodilatation (FMD) (a) and asymmetrical dimethyl arginine (ADMA) (b). Kidney International  , DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions

3 Figure 2 Influence of adjustment of high-sensitivity C-reactive protein (hsCRP), homeostatic model assessment (HOMA) index, and asymmetrical dimethyl arginine (ADMA) on the correlation coefficient (β) of the fibroblast growth factor (FGF-23)–flow-mediated vasodilatation (FMD) relationship. The correlation coefficient was unaffected by hsCRP and HOMA but was substantially attenuated after adjustment for ADMA. Nonetheless, also after adjustment for ADMA, the FGF-23–FMD link remained highly significant (P=0.009). Kidney International  , DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions


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