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Ontogeny of platelet function

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Presentation on theme: "Ontogeny of platelet function"— Presentation transcript:

1 Ontogeny of platelet function
by Andreas Margraf, Claudia Nussbaum, and Markus Sperandio BloodAdv Volume 3(4): February 26, 2019 © 2019 by The American Society of Hematology

2 Andreas Margraf et al. Blood Adv 2019;3:692-703
© 2019 by The American Society of Hematology

3 Important platelet expression and activation responses in the neonate.
Andreas Margraf et al. Blood Adv 2019;3: © 2019 by The American Society of Hematology

4 Ontogenetic regulation of platelet function.
Ontogenetic regulation of platelet function. Experimental data suggest a balanced environment in which platelet function is tightly regulated to achieve an age-dependent modulation of platelet responses. Andreas Margraf et al. Blood Adv 2019;3: © 2019 by The American Society of Hematology

5 Age-mismatch transfusion of platelet concentrates and possible adverse events.
Age-mismatch transfusion of platelet concentrates and possible adverse events. Currently, platelet concentrates are collected from adult donors. Adult platelets feature a distinct phenotype that is different from the physiologic properties of neonatal platelets. Possible harmful effects have to be considered and investigated in more detail. TRALI, transfusion-related acute lung injury; ulVWF, unusually large VWF. Andreas Margraf et al. Blood Adv 2019;3: © 2019 by The American Society of Hematology


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