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Figure 2 Peripheral blood lymphocyte subset counts during dimethyl fumarate treatment(A) Lymphocyte subsets were obtained at baseline (n = 21) and at month.

Published byTania Mertens Modified over 5 years ago

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Presentation on theme: "Figure 2 Peripheral blood lymphocyte subset counts during dimethyl fumarate treatment(A) Lymphocyte subsets were obtained at baseline (n = 21) and at month."— Presentation transcript:

1 Figure 2 Peripheral blood lymphocyte subset counts during dimethyl fumarate treatment(A) Lymphocyte subsets were obtained at baseline (n = 21) and at month 3 (n = 13), month 6 (n = 13), and month 12 (n = 14) of treatment. Peripheral blood lymphocyte subset counts during dimethyl fumarate treatment(A) Lymphocyte subsets were obtained at baseline (n = 21) and at month 3 (n = 13), month 6 (n = 13), and month 12 (n = 14) of treatment. Red lines represent lower limit of normal for each subset. Statistical significance was computed using Mann-Whitney U test. (B) Paired longitudinal analysis (n = 11) of CD4 counts, CD8 counts, and CD4/CD8 ratio between baseline and month 12. Percent reduction of CD4 and CD8 counts from baseline to month 12 was calculated for each individual. The mean reduction of CD8+ T cells (55.5%) was significantly greater than the reduction in CD4+ T cells (43.4%) (p = 0.007). The CD4/CD8 ratio increased by 38.3% at month 12. p Values less than 0.05 were considered statistically significant. *p < 0.05; **p < 0.01; ***p < Collin M. Spencer et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e76 © 2015 American Academy of Neurology

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