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CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.

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Presentation on theme: "CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair."— Presentation transcript:

1 CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation
CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation ASubjective assessment of hair depigmentation (score 0–5, with 0 = completely black and 5 = completely white) at two doses of either CNP520 or the BACE‐1/‐2 inhibitor NB‐360 (Shimshek et al, 2016; mean ± SEM, n = 8/group), statistical comparisons were made for every scoring day, versus vehicle using Kruskal–Wallis with Dunn's post hoc test.BSummary of doses, steady‐state effects on Aβ40 in brain (% compared to vehicle‐treated mice) and the ratios between total skin concentrations of CNP520 and NB‐360 and their respective IC50 values for inhibition of BACE‐2 in vitro. Ulf Neumann et al. EMBO Mol Med. 2018;10:e9316 © as stated in the article, figure or figure legend

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