Download presentation
Presentation is loading. Please wait.
Published byStefan Król Modified over 5 years ago
1
Insights in the Understanding of Cholesterol Metabolism:
2
Table of Contents
3
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Pathway
4
Hepatic LDLRs Play a Central Role in Cholesterol Homeostasis
5
Recycling of LDLRs Enables Efficient Clearance of LDL-C Particles
7
Genetic Variants of PCSK9 Demonstrate Its Importance in Regulating LDL Levels
8
Gain-of-Function Mutations in PCSK9 Cause Familial Hypercholesterolemia*†
9
Loss-of-Function Mutations in PCSK9 Are Associated With Decreased LDL-C
11
Expression of PCSK9 Depends on Intracellular Cholesterol Levels
12
Summary
13
Genetic Variants of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)
14
PCSK9 Mutations Are Involved in Familial Hypercholesterolemia
15
PCSK9 is a Key Regulator of LDLR Recycling
16
Regulation of PCSK9 is Dynamic
17
Genetic Variants of PCSK9 Demonstrate its Importance in Regulating LDL Levels
18
PCSK9 GOF Mutations
19
Clinical Outcomes Associated With Genetic Mutations for Gain of PCSK9 Function
20
Case Reports Highlight Hypercholesterolemia Associated With PCSK9 GOF Mutations
21
GOF Mutations Are Associated With Increased ApoB-Containing Lipoproteins in Humans
22
PCSK9 GOF Mutations Associated With FH*1
23
PCSK9 LOF Mutations
24
Clinical Outcomes Associated With Genetic Mutations for Loss of PCSK9 Function
25
PCSK9 LOF Mutations Are Associated With Decreased Plasma LDL-C Concentrations
26
PCSK9 LOF Mutations and Variants Associated With Hypocholesterolemia
27
PCSK9 LOF Compound Heterozygote With No Detectable Circulating PCSK9
28
PCSK9C679X-Associated Cholesterol Lowering in a Population With Low LDL-C
29
Summary
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.