1. a b c d OGTT OGTT *** ** * * Blood glucose (mg/dL) AUC (mg/dL/min) ND
150 ** ND
250
HFD *
200
120 *
Blood glucose (mg/dL)
AUC (mg/dL/min)
150 90
100 60 50 30 60 90
120 ND
HFD
Time (min) c d *
IPITT
IPITT 80 ND **
HFD
***
*** 60
150
***
Blood glucose (mg/dL) 40
100
AUC (mg/dL/min) 20 50 30 60 90
120 ND
HFD
Time (min)
Supplemental Fig. 1. Impaired glucose tolerance and insulin sensitivity in diet-induced obese rats. Blood glucose levels (a, c) and AUC (b, d) during OGTT and IPITT in rats fed a normal diet (ND) or a high-fat diet (HFD). Statistical differences were analyzed by using one-way ANOVA followed by a Tukey’s post-hoc test or a Student’s t test, where appropriate. *P<0.05, **P<0.01 vs control rats fed a ND.