1. Volume 69, Issue 11, Pages 1925-1927 (June 2006)
Rapamycin and chronic kidney disease: beyond the inhibition of inflammation 
Y. Liu 
Kidney International 
Volume 69, Issue 11, Pages (June 2006)
DOI: /sj.ki
Copyright © 2006 International Society of Nephrology Terms and Conditions

2. Figure 1
Potential actions of rapamycin in chronic renal fibrosis. Mammalian target of rapamycin (mTOR), through its downstream effectors, plays a critical role in regulating a variety of cellular processes, such as cell proliferation and hypertrophy, T-cell infiltration and clonal expansion, and tubular epithelial-to-mesenchymal transition (EMT). Arrows represent activation, and bars represent inhibition. p70S6K, p70 ribosomal S6 kinase; 4E-BP1, eukaryotic initiation factor-4E-binding protein-1; eIF-4E, eukaryotic initiation factor-4E; cdk, cyclin-dependent kinase.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2006 International Society of Nephrology Terms and Conditions