1. Mathematical modeling of affinities between measured species
Mathematical modeling of affinities between measured species Schematic graph of the mathematical model describing concentration distributions of measured species in mitotic ROIs. Spatial distributions are explained by affinities of species to cellular structures contained in mitotic ROIs αil as well as homo‐ or heterodimeric interactions in ROIs described by affinities βij. Affinities are defined as the inverse of dissociation constants (, unbound species i; xil, bound species i in ROI l, xil:xjl, heterodimer of species i and j in ROI l; see Materials and Methods for details).Affinities related to known protein–protein interactions from Ingenuity Pathway Analysis overlaid with additional predicted mutual affinities between measured proteins. Known affinities that significantly contributed to explaining the measured intensity distributions were marked by black squares. For affinities to mitotic ROIs, see Appendix Fig S2.Estimates of mutual affinities between measured proteins for untreated cells.Estimated mutual affinities between measured proteins after treatment with PLK1 inhibitor.
Lorenz J Maier et al. Mol Syst Biol 2018;14:e8238
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