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Volume 70, Issue 3, Pages 552-554 (March 2019)
Successful HCV treatment of patients on contraindicated anti-epileptic drugs: Role of drug level monitoring Minou van Seyen, Elise J. Smolders, Peter van Wijngaarden, Joost P.H. Drenth, Marjan Wouthuyzen-Bakker, Robert J. de Knegt, Pieter Honkoop, Omar El-Sherif, Angela Colbers, David J. Back, David M. Burger Journal of Hepatology Volume 70, Issue 3, Pages (March 2019) DOI: /j.jhep Copyright © 2018 European Association for the Study of the Liver Terms and Conditions
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Fig. 1 Pharmacokinetic curves of daclatasvir, sofosbuvir and GS in patients on contraindicated anti-epileptic drugs. (A) Daclatasvir standard dose of 60mg once daily was adjusted to 60mg twice daily for patient 1 and 2 and 60mg 3 times a day for patients 3–6, to compensate for the expected reduced exposure. For patient 2, the dose was further increased to 60mg 3 times a day (curve 2b) due to low exposure on 60mg twice daily (curve 2a). The reference curve shows daclatasvir 60mg once daily in hepatitis C genotype 1-infected patients without cirrhosis and contraindicated medication.10 Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions
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