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Incidence of chromosomal mosaicism in morphologically normal nonhuman primate preimplantation embryos  Cathérine Dupont, Ph.D., James Segars, M.D., Alan.

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Presentation on theme: "Incidence of chromosomal mosaicism in morphologically normal nonhuman primate preimplantation embryos  Cathérine Dupont, Ph.D., James Segars, M.D., Alan."— Presentation transcript:

1 Incidence of chromosomal mosaicism in morphologically normal nonhuman primate preimplantation embryos  Cathérine Dupont, Ph.D., James Segars, M.D., Alan DeCherney, M.D., Barry D. Bavister, Ph.D., D. Randall Armant, Ph.D., Carol A. Brenner, Ph.D.  Fertility and Sterility  Volume 93, Issue 8, Pages (May 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Mechanistic models for post-zygotic chromosomal errors in preimplantation embryos. (A) Mitotic nondisjunction, identified by the presence of blastomeres with a trisomy compensated by a monosomy in another blastomere. (B and E) Anaphase lagging or minor fragmentation of the nucleus and blastomere, identified when monosomies in certain blastomeres are not compensated by trisomies in other blastomeres. (C and D) Splitting or major fragmentation of the nucleus and blastomere, identified by the presence of blastomeres with split or fragmented chromosomal complements. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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