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Volume 134, Issue 7, Pages (June 2008)

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1 Volume 134, Issue 7, Pages 2070-2079 (June 2008)
A Rat Model of Chronic Gastric Sensorimotor Dysfunction Resulting From Transient Neonatal Gastric Irritation  Lian–Sheng Liu, John H. Winston, Mohan M. Shenoy, Geng–Qing Song, Jiande D.Z. Chen, Pankaj Jay Pasricha  Gastroenterology  Volume 134, Issue 7, Pages (June 2008) DOI: /j.gastro Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Change in body weight in the 2 experimental groups (see Results section for details). *P < .05. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 Gastric morphology (A) and MPO activity (B) in neonatal rats exposed to IA or sucrose. Changes in gastric morphology (C) and MPO activity (D) of adult rats (8 weeks old) neonatally treated with IA or sucrose. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 (A) Behavioral response of IA-treated (as neonates) rats at 8 weeks was significantly higher compared with controls. (B) Representative EMG response from an adult rat to gastric distention treated with either intragastric IA or sucrose as neonates. (C) IA-treated rats exhibited significantly greater EMG responses compared with controls at 60 and 80 mmHg. *P < .05. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

5 Figure 4 (A) Representative response of GSN afferent fibers from an adult rat treated either with IA or sucrose (as neonate) to gastric distention. (B) Comparisons of the spontaneous background activity of GSN primary afferent fibers in IA-treated and sucrose-treated rats. (C) Compared with control, GSN responses in the IA-treated rats were significantly greater at 60- and 80-mm Hg GD. (D) The response of LT fibers to all 4 distention pressures was compared by 2-way ANOVA. (E) The response of HT fibers to 3 distention pressures (40, 60, and 80 mm Hg) was compared by 2-way ANOVA. *P < .05. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

6 Figure 5 (A) Food intake during 3 hours was lower in IA-treated rats compared with controls, and gastric content 3 hours postfood intake was no different between the 2 groups. (B) There was no difference in the rate of gastric emptying between the 2 groups. *P < .05. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

7 Figure 6 Gastric pressure-volume relationship in adult rats. The average volumes of the IA-treated rats were significantly lower when compared with controls in ramp phase. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions


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