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Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: An in silico analysis  John A. Jenkins, PhD, Sam Griffiths-Jones,

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Presentation on theme: "Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: An in silico analysis  John A. Jenkins, PhD, Sam Griffiths-Jones,"— Presentation transcript:

1 Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: An in silico analysis  John A. Jenkins, PhD, Sam Griffiths-Jones, PhD, Peter R. Shewry, PhD, Heimo Breiteneder, PhD, E.N. Clare Mills, PhD  Journal of Allergy and Clinical Immunology  Volume 115, Issue 1, Pages (January 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Distribution within protein families, as classified by Pfam using allergen sequences from the PROTALL and FARRP databases. A, PROTALL-FARRP (black); PROTALL food allergen (gray); PROTALL-FARRP (single sequence per allergen; white); B, FARRP respiratory allergen set. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Conserved surface residues in the Bet v 1 family. A, Ribbon diagram of Bet v 1a. B, Conserved residues between Bet v 1a and Mal d 1 showing side chains (red), main chains (pink), and nonconserved side chains/main chains (cyan). C, Conserved residues, as in B, for Bet v 1a–Gly m 4 conservation, with P-loop marked. D, Conserved residues, as in B, for Bet v 1a–Api g conservation, with most similar surface region marked. An animated (video) version of this figure is available in the Journal's Online Repository at Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Conserved surface residues in the nsLTP family. A, Ribbon diagram of corn nsLTP, Zea m 14. B, Surface of Zea m 14, colored to show Pru p 3–Zea m 14 conservation, as in Fig 2. C, Ribbon diagram of wheat nsLTP1. D, Surface of wheat nsLTP, colored to show Pru p 3–wheat conservation, as in Fig 2. An animated (video) version of this figure is available in the Journal's Online Repository at Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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