1. Three drug delivery strategies for crossing the blood-brain barrier.
Three drug delivery strategies for crossing the blood-brain barrier. In receptor-mediated endocytosis, a drug is conjugated to a ligand that binds to a receptor on the blood-brain barrier to trigger endocytosis. Small lipophilic compounds can be taken up by passive diffusion. Carrier-mediated transport is driven by two major protein families, the solute carrier superfamily and ATP binding cassette transporters, and these transporters can be hijacked for drug delivery.
Andrea Shergalis et al. Pharmacol Rev 2018;70:
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