1. Enhanced expression of TLR7 protein in PBMCs from women.
Enhanced expression of TLR7 protein in PBMCs from women. The TLR7 140-kDa (full-length; A) and 75-kDa (proteolytically mature; B) forms of the protein were quantitated separately and normalized to β-actin in three Western blot experiments on nonstimulated PBMCs. Cells from 26 males and 26 females were analyzed, and the measurements for female cells were normalized to the mean for male cells in each experiment. The donors were all hemizygous or homozygous for the major alleles of the exonic TLR7 SNPs, namely, allele A of rs and allele C of rs P values from Student’s t test.
Mélanie Souyris et al. Sci. Immunol. 2018;3:eaap8855
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