1. Apollo—Taking the Lead in Telomere Protection
Jay F. Sarthy, Peter Baumann 
Molecular Cell 
Volume 39, Issue 4, Pages (August 2010)
DOI: /j.molcel
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1
Resection of the 5′ End by Apollo Following Leading-Strand Synthesis Provides Binding Sites for POT1/TPP1 and Permits Formation of a Protective Structure that Prevents ATM Activation
The lagging-strand telomere gains a 3′ overhang by removal of the RNA primer used in DNA synthesis. Further resection by Apollo or another nuclease may also occur. Newly synthesized strands are shown in red. In the absence of Apollo, a DNA damage response (DDR) is triggered at blunt leading-strand telomeres, resulting in their fusions, whereas lagging-strand telomeres are protected. During replication, active Apollo resolves structures that impede replication (indicated by black box) ahead of the fork. When Apollo is absent or inactive, replication problems trigger a DDR.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2010 Elsevier Inc. Terms and Conditions