1. Volume 86, Issue 2, Pages 383-391 (August 2014)
Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function 
Ting Jia, Xiaoyan Huang, Abdul R. Qureshi, Hong Xu, Johan Ärnlöv, Bengt Lindholm, Tommy Cederholm, Peter Stenvinkel, Ulf Risérus, Juan J. Carrero 
Kidney International 
Volume 86, Issue 2, Pages (August 2014)
DOI: /ki
Copyright © 2014 International Society of Nephrology Terms and Conditions

2. Figure 1
Reliability coefficients between insulin sensitivity indices and M/I as estimated by hyperinsulinemic euglycemic glucose clamps in subjects without (black bars) and with (white bars) manifest chronic kidney disease. Data are shown as 4 × 4 weighted κ and 95% confidence intervals. AUCins, area under the curve for insulin; FIRI, fasting insulin resistance index; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-AD, homeostasis model assessment corrected by adiponectin; OGTT, oral glucose tolerance test; QUICKI, quantitative insulin sensitivity check index.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions

3. Figure 2
Comparison between measured M/I and predicted M/I from QUICKI and Matsuda indices in non-CKD (N=579) subjects and CKD subjects (N=495). Predicted M/I was calculated using the leave-one-out cross-validation analysis of the calibration models, as described in Materials and Methods. The solid line indicates ideal predictive accuracy. Square of correlation coefficients (r2) is shown in each panel. Circle symbols represent non-CKD participants and square symbols represent CKD participants. CKD, chronic kidney disease; QUICKI, quantitative insulin sensitivity check index.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions

4. Figure 3
Comparison of receiver operating characteristic (ROC) curves for QUICKI and Matsuda indices to predict a state of insulin resistance (M<4mg/kg/min) in CKD and non-CKD subjects. Data are shown as sensitivity/1-specificity curves. The black curve represents the Matsuda index and the gray curve represents QUICKI. The comparison of the two AUC was tested by binomial exact confidence interval. AUC, areas under curves; CKD, chronic kidney disease; QUICKI, quantitative insulin sensitivity check index; ROC, receiver operating characteristic.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions