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Volume 70, Issue 11, Pages (December 2006)

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Presentation on theme: "Volume 70, Issue 11, Pages (December 2006)"— Presentation transcript:

1 Volume 70, Issue 11, Pages 1891-1893 (December 2006)
4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?  M.B. Coulter-Mackie  Kidney International  Volume 70, Issue 11, Pages (December 2006) DOI: /sj.ki Copyright © 2006 International Society of Nephrology Terms and Conditions

2 Figure 1 Simplified metabolic pathways leading to glyoxylate and oxalate. This figure outlines the major reactions under discussion, their subcellular locations, and potential sites for intervention to achieve substrate (glyoxylate) depletion. AGT, alanine:glyoxylate aminotransferase; DAO, D-amino acid oxidase; GO, glycolate oxidase; GR, glyoxylate reductase; LDH, lactate dehydrogenase; HKGA, 4-hydroxy-2-ketoglutarate lyase. Solid arrows: enzymatic reactions; broken arrows: transport: proposed sites for intervention. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions


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