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Highly Sensitive Detection of EGFR T790M Mutation in Pre-TKI Specimens of EGFR- Mutated NSCLC: In Cis, In Trans, or a Different Clone?  Alvaro Leone, BSc.D 

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Presentation on theme: "Highly Sensitive Detection of EGFR T790M Mutation in Pre-TKI Specimens of EGFR- Mutated NSCLC: In Cis, In Trans, or a Different Clone?  Alvaro Leone, BSc.D "— Presentation transcript:

1 Highly Sensitive Detection of EGFR T790M Mutation in Pre-TKI Specimens of EGFR- Mutated NSCLC: In Cis, In Trans, or a Different Clone?  Alvaro Leone, BSc.D  Journal of Thoracic Oncology  Volume 8, Issue 3, Pages e26-e27 (March 2013) DOI: /JTO.0b013e31827e2467 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Putative scenarios of tumor evolution after TKI therapy. Black circles, cells with EGFR activating mutation; red circles, cells with activating or resistant mutation; Black lines, different alleles; black arrowhead, activating mutation; red arrowhead, resistant mutation. TKI, tyrosine kinase inhibitor. Journal of Thoracic Oncology 2013 8, e26-e27DOI: ( /JTO.0b013e31827e2467) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

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