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Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion

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Presentation on theme: "Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion"— Presentation transcript:

1 Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion
SORL1 mutants' overexpression increases β-amyloid secretion (A–C) Secreted β-amyloid 40 (Aβ40), Aβ42, and amyloid precursor protein soluble β-secretase (APPsβ) were measured from culture medium in stable HEK293 cells expressing the APP Swedish mutant (HEKsw) together with either wild-type SORL1 or mutant SORL1. Error bars represent standard error of the mean (SEM). ***p < 0.001, *p < 0.05, ns, not significant, n = 3 independent replications. (D) Western blot was performed to detect APP soluble α-secretase (APPsα) from cultured media. Bar graphs were normalized to control. **p < 0.01, n = 3 independent replications, and error bars represent the SEM. Aβ = β-amyloid; FL-APP = full-length APP; SORL1 = sortilin-related receptor. Michael L. Cuccaro et al. Neurol Genet 2016;2:e116 © 2016 American Academy of Neurology

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Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Reduction of SorLA/LR11, a Sorting Protein Limiting.

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