1. a b Supplementary Figure 1 Plasma Vosaroxin (ng/mL) Time (h)20 40 60 80
100
120
140 1 10
1000
10000
18 mg/m 2
n=3
27 mg/m
n=6
38 mg/m
50 mg/m
n=8
60 mg/m
n=4
72 mg/m
n=11
90 mg/m
Plasma Vosaroxin (ng/mL) 50
150
200
250
300
350 a b
Supplementary Figure 1
Leukemia manuscript KF10-LEU-1089RRR
Supplemental Figure 1
Figure 1. Average concentration-time plots by vosaroxin treatment schedule and group in cycle 1. (a), weekly schedule; (b), twice weekly schedule; h, hours. Error bars represent standard error of the mean.