Presentation is loading. Please wait.

Presentation is loading. Please wait.

OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs. OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs.

Published byAdi Sudirman Modified over 5 years ago

Similar presentations

Presentation on theme: "OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs. OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs."— Presentation transcript:

1 OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs.
OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs. (A) Fundus photography and direct GFP fluorescence detection 2 wk postinjection of the AAVs in WT C57Bl/6J animals. The site of injection is marked by an asterisk (*, red). (B) Representative OCT scans indicating normal morphology and lamination 1 mo postinjection with AAV-GFP and AAV-Cre. (C) Quantification of total retinal thickness indicating no change in GFP- versus Cre-transduced WT animals (n = 5). (D) Scotopic ERG measurements of the a-, b-, and c-wave amplitudes and implicit time 1 mo postinjection (n = 12). Error bars are means ± SEM. Unpaired t tests were used in all comparisons. No statistical difference was determined between the cohorts. Mariana Aparecida Brunini Rosales et al. LSA 2019;2:e © 2019 Rosales et al.

Download ppt "OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs. OCT and ERG analysis of wild-type mice 2 and 4 wk after injection with AAVs."

Similar presentations

Volume 3, Issue 5, Pages (May 2001)

Volume 3, Issue 5, Pages (May 2001)
From: Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide Invest. Ophthalmol. Vis. Sci.. 2016;57(2):372-386.

From: Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide Invest. Ophthalmol. Vis. Sci ;57(2):
Reduced scar formation in the injured GM of CCR2−/− mice

Reduced scar formation in the injured GM of CCR2−/− mice
Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-
Summary of fusion event frequency for wild-type (wt) and Cav1

Summary of fusion event frequency for wild-type (wt) and Cav1
Klotho reduction in CP primes hippocampal microglia for activation.

Klotho reduction in CP primes hippocampal microglia for activation.
Klotho depletion increases MHC class II expression in the CP

Klotho depletion increases MHC class II expression in the CP
Klotho reduction causes macrophage invasion into the CP

Klotho reduction causes macrophage invasion into the CP
Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO.

Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO.
Aberrant wound architecture and proliferation in Rev3l-deficient skin.

Aberrant wound architecture and proliferation in Rev3l-deficient skin.
Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.
The STM1787 promoter in Salmonella is rapidly activated in vivo by the tumor microenvironment. The STM1787 promoter in Salmonella is rapidly activated.

The STM1787 promoter in Salmonella is rapidly activated in vivo by the tumor microenvironment. The STM1787 promoter in Salmonella is rapidly activated.
Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.
Loss of Ifnar1 signaling elicits inflammatory processes and angiogenesis in laser‐induced retinal damage Loss of Ifnar1 signaling elicits inflammatory.

Loss of Ifnar1 signaling elicits inflammatory processes and angiogenesis in laser‐induced retinal damage Loss of Ifnar1 signaling elicits inflammatory.
IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization AExperimental.

IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization AExperimental.
Volume 73, Issue 3, Pages (February 2012)

Volume 73, Issue 3, Pages (February 2012)
Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding, or TPA. Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding,

Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding, or TPA. Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding,
Voluntary but not forced exercise alters food consumption in mice.

Voluntary but not forced exercise alters food consumption in mice.
Volume 25, Issue 3, Pages (March 2017)

Volume 25, Issue 3, Pages (March 2017)
Molecular Therapy - Methods & Clinical Development

Molecular Therapy - Methods & Clinical Development

Similar presentations

Ads by Google