1. Welcome to this program, titled De-Escalating Therapy in Epilepsy: A Return to Monotherapy

2. Introduction

3. Combination Therapy

4. Difficult to Treat Epilepsy

5. Seizure Control With Switching

6. Patient Selection for Monotherapy

7. Seizure Control With Switching

8. Which Drug to Withdraw?

9. Strategies for Converting to Monotherapy

10. Available AEDs for Monotherapy

11. Monotherapy Clinical Trial Limitations

12. Clinical Trials Design

13. The Future of Monotherapy Approvals

14. Drug-Drug Interactions

15. Drug-Drug Interactions (cont)

16. Epilepsy and Comorbidities

17. Benefits of Monotherapy

18. Mechanisms of Action of AEDs

19. Conclusions

20. Abbreviations