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Autocrine Growth by Granulocyte Colony-Stimulating Factor in Malignant Mesothelioma  Motohiro Nishimura, MD, PhD, Kyoko Itoh, MD, PhD, Kazuhiro Ito, MD,

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1 Autocrine Growth by Granulocyte Colony-Stimulating Factor in Malignant Mesothelioma 
Motohiro Nishimura, MD, PhD, Kyoko Itoh, MD, PhD, Kazuhiro Ito, MD, PhD, Masashi Yanada, MD, Kunihiko Terauchi, MD, Shinji Fushiki, MD, PhD, Junichi Shimada, MD, PhD  The Annals of Thoracic Surgery  Volume 82, Issue 5, Pages (November 2006) DOI: /j.athoracsur Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 (A) The tumor showed interwoven bundles of spindle cells and diffuse infiltrates of epithelioid cells (left field) with abundant cytoplasm and irregular nuclei. The infiltration of leukocytes was frequently found in the tumor. (B) Intense granulocyte-colony stimulating factor (G-CSF) immunoreactivity was found in the cytoplasm of many tumor cells. (C) More abundant immunoreactivity for G-CSF receptor was recognized in the cytoplasm of tumor cells and endothelial cells. ([A]: hematoxylin-eosin; [B]: immunohistochemistry for human G-CSF; and [C]: immunohistochemistry for human G-CSF receptor.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions


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