1. CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn’s disease 
Subra Kugathasan, Nicole Collins, Karen Maresso, Raymond G. Hoffmann, Michael Stephens, Steven L. Werlin, Colin Rudolph, Ulrich Broeckel 
Clinical Gastroenterology and Hepatology 
Volume 2, Issue 11, Pages (November 2004)
DOI: /S (04)
Copyright © 2004 American Gastroenterological Association Terms and Conditions

2. Figure 1
Kaplan-Meier analysis showing patients without surgery according to the time between the diagnosis and surgery in CD without 3020insC (solid line, n = 112), and children with CD who carry at least one allele of 3020insC variant (interrupted line). There was a significant risk for surgery (P < .0001; hazard ratio, 5.8) in children with CD who carry 3020insC compared with children with CD without 3020insC during the follow-up evaluation.
Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04) )
Copyright © 2004 American Gastroenterological Association Terms and Conditions