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Schematic representation of experimental design for BSp dietary treatments. Schematic representation of experimental design for BSp dietary treatments.

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Presentation on theme: "Schematic representation of experimental design for BSp dietary treatments. Schematic representation of experimental design for BSp dietary treatments."— Presentation transcript:

1 Schematic representation of experimental design for BSp dietary treatments.
Schematic representation of experimental design for BSp dietary treatments. The upper bar represents different life stages in the mother and female offspring. Transgenic mice were administered the BSp diet under different exposure time points: (i) Control: mice were fed ad libitum (AL) with the control AIN-93G diet; (ii) prenatal/maternal BSp treatment (Pre-BSp): The BSp diet was given to the mother from conception (12 weeks) until weaning (PD28); (iii) postnatal early-life BSp treatment (Early-BSp): The BSp diet from postnatal 4 weeks of age until termination of the experiment; (iv) postnatal adult BSp treatment (Adult-BSp): The BSp diet from postnatal 8 weeks of age until termination of the experiment. Mice were mated at 12 weeks of age following 3 weeks of gestation. Pups were weaned at 4 weeks of age (PD28). In the prenatal/maternal BSp group, weaned female offspring were maintained on the control diet throughout their lifespan until termination of the experiment and monitored for tumor growth weekly. For postnatal treatments, female mice were born to mothers administered the control AIN-93G diet and monitored for tumor growth weekly after weaning. Yuanyuan Li et al. Cancer Prev Res 2018;11: ©2018 by American Association for Cancer Research

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