1. Latest findings in phosphate homeostasis
Dominique Prié, Pablo Ureña Torres, Gérard Friedlander 
Kidney International 
Volume 75, Issue 9, Pages (May 2009)
DOI: /ki
Copyright © 2009 International Society of Nephrology Terms and Conditions

2. Figure 1
Proteins involved in renal phosphate reabsorption. Phosphate is reabsorbed in the proximal tubular cells through two sodium phosphate cotransporters, NPT2a and NPT2c, the activity of which is controlled by two hormones; the parathyroid hormone (PTH) and the fibroblast growth factor 23 (FGF23). PTH binds to the PTH type1 receptor (PTHR1) and induces the retrieval of NPT2a from the brush border membrane. Its effect on NPT2c is uncertain. FGF23 decreases the expression of both sodium phosphate cotransporters. NHERF1 binds to NPT2a and type 1 PTH receptor (PTH1R). Mutations in all these proteins have been identified in humans with impaired renal phosphate reabsorption.
Kidney International  , DOI: ( /ki )
Copyright © 2009 International Society of Nephrology Terms and Conditions

3. Figure 2
FGF23 and the bone–kidney axis. The fibroblast growth factor 23 (FGF23) is synthesized by bone in response to an increase in serum phosphate concentration. FGF23 controls renal phosphate transporter activity and calcitriol synthesis by the proximal tubule and intestinal phosphate absorption through calcitriol level. FGF23 may also alter parathyroid gland functions.
Kidney International  , DOI: ( /ki )
Copyright © 2009 International Society of Nephrology Terms and Conditions