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Both sexual experience and ΔFosB increase dendritic spines in vmPFC.

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Presentation on theme: "Both sexual experience and ΔFosB increase dendritic spines in vmPFC."— Presentation transcript:

1 Both sexual experience and ΔFosB increase dendritic spines in vmPFC.
Both sexual experience and ΔFosB increase dendritic spines in vmPFC. A, AAV-GFP was injected into the IL of naive (n = 22) or sexually experienced (n = 21) males, and AAV-GFP-ΔFosB was injected into the IL of naive males (n = 22). Immunofluorescence using a GFP antibody reveals spines of IL pyramidal neurons in all three groups. B, Thin spine density was increased by ΔFosB overexpression. Stubby spine density was not affected by either sexual experience nor ΔFosB overexpression. Mushroom spine density increased with sexual experience and showed a trend to increase by ΔFosB overexpression. Overall, total spine density was increased by ΔFosB overexpression. Bars represent mean (±SEM). *Main effect of experimental group, p < 0.05. Kayla C. De Lorme et al. eNeuro 2019;6:ENEURO ©2019 by Society for Neuroscience

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