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Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma  Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD,

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Presentation on theme: "Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma  Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD,"— Presentation transcript:

1 Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma  Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD, Takafumi Koga, MD, Yamato Motooka, MD, Kosuke Fujino, MD, Hidekatsu Shibata, MD, PhD, Takeshi Mori, MD, PhD, Makoto Suzuki, MD, PhD  The Annals of Thoracic Surgery  Volume 99, Issue 5, Pages (May 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Representative images of immunohistological staining for SLC5A8 in tumors from the (A) high expression group and the (B) low expression group (original magnification ×200). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Kaplan-Meier curves for disease-free survival of patients based on stage of adenocarcinoma: pathologic stage I (solid line) and stage II (dashed line). Patients with stage II cancer showed significantly shorter disease-free survival than patients with stage I cancer (p <0.001). (B) Kaplan-Meier curves for disease-free survival of patients based on SLC5A8 methylation rates: nonhypermethylation group (<7.75% [solid line]) and hypermethylation group (≥7.75% [dashed line]). Patients in the hypermethylation group showed significantly shorter disease-free survival than patients in the nonhypermethylation group (p = 0.02). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

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