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Prevalence and impact of abnormal ROTEM® assays in severe blunt trauma: results of the ‘Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC)

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Presentation on theme: "Prevalence and impact of abnormal ROTEM® assays in severe blunt trauma: results of the ‘Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC)"— Presentation transcript:

1 Prevalence and impact of abnormal ROTEM® assays in severe blunt trauma: results of the ‘Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study’  H. Tauber, P. Innerhofer, R. Breitkopf, I. Westermann, R. Beer, R. El Attal, A. Strasak, M. Mittermayr  British Journal of Anaesthesia  Volume 107, Issue 3, Pages (September 2011) DOI: /bja/aer158 Copyright © 2011 The Author(s) Terms and Conditions

2 Fig 1 Prevalence (95% CI) of clinically relevant abnormal coagulation tests in patients with isolated brain injury (black lines, n=60) and those with polytrauma (red lines, n=274). Extrinsically activated ROTEM® parameters are FIBTEM MCF, EXTEM MCF, EXTEM CFT, and EXTEM CT. Standard laboratory parameters are fibrinogen concentration (fibrinogen), platelet count (platelets), aPTT, and INR. *P<0.05 polytrauma vs isolated brain injury (Fisher’s exact test) British Journal of Anaesthesia  , DOI: ( /bja/aer158) Copyright © 2011 The Author(s) Terms and Conditions

3 Fig 2 Relation of plasmatic test results [PT, aPTT, antithrombin activity (AT), fibrinogen concentration, platelet count], base excess (BE), extrinsically activated ROTEM® parameters (EXTEM CT, CFT, MCF, FIBTEM MCF), prothrombin fragments (F1+2) and TAT in polytrauma patients according to ISS grouped as ISS 15–29 (n=104), 30–50 (n=116), and 50–75 (n=54). The Kruskal–Wallis test and the Mann–Whitney U-tests were used for analysing differences between ISS groups. *P<0.05 when compared with the ISS group 15–29, #P<0.05 when compared with the ISS group 30–50. British Journal of Anaesthesia  , DOI: ( /bja/aer158) Copyright © 2011 The Author(s) Terms and Conditions


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