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Genetics and Etiopathophysiology of Schizophrenia

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Presentation on theme: "Genetics and Etiopathophysiology of Schizophrenia"— Presentation transcript:

1 Genetics and Etiopathophysiology of Schizophrenia
Janet L. Sobell, PhD, Marci J. Mikesell, PhD, Cynthia T. McMurray, PhD  Mayo Clinic Proceedings  Volume 77, Issue 10, Pages (October 2002) DOI: / Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Major pathways of the dopamine system in the brain. CA = caudate; NuAcc = nucleus accumbens; PFC = prefrontal cortex; PUT = putamen; SN = substantia nigra; VTA = ventral tegmental area. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 Pedigree of schizophrenia family displaying anticipation. This representative pedigree from the study of Bassett and Honer135 shows the occurrence of anticipation in 8 Eastern Canadian schizophrenia families. GG = grandparental generation; IG = index generation; PG = parental generation. Numbers below each individual indicate their age in years at first hospitalization for psychotic illness. Closed symbols indicate affected individuals; half-closed symbols indicate the presence of schizotypal conditions; open symbols indicate unaffected individuals. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions


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