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A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization  Nathalie Lédée-Bataille,

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Presentation on theme: "A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization  Nathalie Lédée-Bataille,"— Presentation transcript:

1 A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization  Nathalie Lédée-Bataille, M.D., Ph.D., Sylvie Dubanchet, Aurore Coulomb-L'hermine, M.D., Ingrid Durand-Gasselin, René Frydman, M.D., Gérard Chaouat, M.D., Ph.D.  Fertility and Sterility  Volume 81, Issue 1, Pages (January 2004) DOI: /j.fertnstert

2 FIGURE 1 Anti–IL-12 labeling of the endometrium during the luteal phase for a fertile control patient (A); for a patient with an excess of IL12 (B); and for a patient without IL-12 staining (C). The figure shows the necessity of a delicate balance, where both depletion and excess are deleterious for further implantation. Original magnification, ×100. Lédée-Bataille. New role for IL-12 and IL-18 in IVF. Fertil Steril 2004. Fertility and Sterility  , 59-65DOI: ( /j.fertnstert )

3 FIGURE 2 Anti-CD56 labeling of the endometrium during the luteal phase. (A) Control fertile patient (NK count = 10/field); (B) Patient with implantation failure and NK excess pattern (NK = 135/field). Original magnification, ×100. Lédée-Bataille. New role for IL-12 and IL-18 in IVF. Fertil Steril 2004. Fertility and Sterility  , 59-65DOI: ( /j.fertnstert )


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