1. Liver GADD45β expression modulates glucose homoeostatic control in type 2 diabetes
Liver GADD45β expression modulates glucose homoeostatic control in type 2 diabetes A–CMale 12‐weeks‐old wild‐type (WT; C57Bl/6J) or obese/diabetic (db/db; BKS.Cg‐m+/+ Lepr DB/J) mice with (AD‐G45b OE) or without (AD‐NC) prior liver‐restricted GADD45β over‐expression were fasted, and blood glucose (A) and serum insulin (B) were measured from which HOMA‐IR was calculated (C) (n = 4–6/group). Data are mean ± SEM. Effect of genotype/viral manipulation, *P < 0.05, **P < 0.01, ***P <  Effect of nutritional state: #P < 0.05, ##P < 0.01, ###P < 0.001.D–FLiver GADD45B mRNA expression from men with (T2D) or without (NGT) type 2 diabetes (n = 14–23/group). ***P <  Scatter plots fasting plasma triglycerides (E) and glucose (F) in correlation with liver GADD45B mRNA expression (n = 37). Inserts show r2 values and P‐values from Spearman's correlation test.Data information: The statistical test used and respective P‐value outputs can be found in Appendix Table S1.
Jessica Fuhrmeister et al. EMBO Mol Med. 2016;8:
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