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Volume 149, Issue 1, Pages 119-129 (July 2015)
Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma Manal M. Hassan, Reham Abdel-Wahab, Ahmed Kaseb, Ahmed Shalaby, Alexandria T. Phan, Hashem B. El-Serag, Ernest Hawk, Jeff Morris, Kanwal Pratap Singh Raghav, Ju-Seog Lee, Jean-Nicolas Vauthey, Gehan Bortus, Harrys A. Torres, Christopher I. Amos, Robert A. Wolff, Donghui Li Gastroenterology Volume 149, Issue 1, Pages (July 2015) DOI: /j.gastro Copyright © 2015 AGA Institute Terms and Conditions
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Figure 1 (A) Frequency of overweight and obesity at various ages during the life cycle before hepatocellular carcinoma diagnosis or control recruitment. (B) Distribution of body mass index status by percentages (overweight, obese) by HCC risk factors in cases and controls in their mid-20s to mid-40s. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions
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Figure 2 (A) Odds ratios and 95% confidence intervals for the association between adulthood overweight (mid- 20s to mid-40s) with hepatocellular carcinoma risk in the absence of major risk factors and with adjustment of confounding factors. (B) Odds ratios and 95% confidence intervals for the association between adulthood obesity (mid- 20s to mid-40s) with hepatocellular carcinoma risk in the absence of major risk factors and with adjustment of confounding factors. For example, the estimated odds ratios for the association between adulthood overweight/obesity and HCC among nondiabetic subjects were 0.9 (95% CI, 0.6–1.4; P = .8) and 3.0 (95% CI, 1.5–5.8; P = .001) respectively, after adjustment for confounding factors including age, ethnicity, HCV, HBV, education level, alcohol drinking, cigarette smoking, physical activity, and family history of cancer. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions
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