1. By alternating cardiac output via pacemakers labelled ‘Untreated’, there was a 182% increase in end-tidal CO2 oscillations compared to stable breathing without intervention labelled ‘Baseline’.
By alternating cardiac output via pacemakers labelled ‘Untreated’, there was a 182% increase in end-tidal CO2 oscillations compared to stable breathing without intervention labelled ‘Baseline’. When dynamic CO2 was applied to the experimentally induced oscillations coincident with peak ventilation, this abolished 57% of the induced oscillations. When dynamic CO2 was applied 180° after peak ventilation there was no significant difference to pacemaker-induced oscillations alone. Degree of ventilatory oscillation during stable breathing ‘Baseline’, with alternation of cardiac output using pacemakers ‘Untreated’, when dynamic CO2 is applied at peak ventilation and following application of dynamic CO2 coincident with trough ventilation.
Resham Baruah et al. Open Heart 2014;1:e000055
©2014 by British Cardiovascular Society