1. Volume 53, Issue 6, Pages 1559-1573 (June 1998)
Antihypertensive treatment of patients with proteinuric renal diseases: Risks or benefits of calcium channel blockers? 
Heinrich J. Kloke, Amanda J. Branten, Frans T. Huysmans, Jack F. Wetzels 
Kidney International 
Volume 53, Issue 6, Pages (June 1998)
DOI: /j x
Copyright © 1998 International Society of Nephrology Terms and Conditions

2. Figure 1
Relationship between the change in blood pressure and the change of proteinuria during treatment with calcium channel blockers in animal models of glomerulosclerosis. Data are derived from the studies in Tables 1 and 2.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

3. Figure 2
Correlation of glomerular injury with overall averaged systolic blood pressure in the rat remnant kidney model. Curve A describes the correlation for rats either untreated or treated with the ACE inhibitor enalapril. Curve B describes the relationship for nifedipine treated rats. Clearly, the slope is shifted to the left, indicating an increased susceptibility to glomerular injury in the nifedipine group. Curve C is a hypothetical curve, based on the assumption that the calcium channnel blockers might be protective via other mechanisms than influencing blood pressure.
Figure adapted from Griffin et al[54].
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

4. Figure 3
Relative changes in albuminuria for groups treated with nifedipine (NIF), other dihydropyridines (DHP), verapamil (VER) or diltiazem (DIL) and angiotensin converting enzyme inhibitors (ACEinh) in humans. Filled symbols indicate groups with diabetes, crosses indicate non-diabetic groups. Bars in the Figure indicate weighed means. Relative changes in mean arterial pressure (MAP) are also given as weighed means. Low/high albuminuria is less/more than 500 mg/24 hours.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

5. Figure 4
Relationship between the change in mean arterial pressure (MAP) and the change in albuminuria during treatment with dihydropyridine calcium channel blockers in humans. (A) The results of all studies. (B) The relationship is shown for studies in which urine was collected in timed intervals during daytime. Open symbols represent studies of patients with an albuminuria of less than 500 mg/24 hours, whereas closed symbols represent studies of patients with an albuminuria of more than 500 mg/24 hours.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions