1. Genetic Involvement in Skin Wound Healing and Scarring in Domestic Pigs: Assessment of Molecular Expression Patterns in (Yorkshire × Red Duroc) × Yorkshire Backcross Animals 
Corrie L. Gallant-Behm, Carol Reno, Helen Tsao, David A. Hart 
Journal of Investigative Dermatology 
Volume 127, Issue 1, Pages (January 2007)
DOI: /sj.jid
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Total wound area of backcross skin wounds over time: percentage of original wound area. Mean±SEM, N=20. **P<0.01 as compared to the original wound area. ‡P<0.01 as compared to the wound area at the time of re-epithelialization.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Histology of backcross wound samples. Sections were stained with hematoxylin and eosin. (a) Normal skin, day 0. (b) Day 7 post-injury; (c) day 14; (d) day 21; (e) day 28; (f) day 35; (g) day 42; (h) day 49; (i) day 56; (j) day 63; and (k) day 70. Bar=250μm.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Collagen orientation in backcross full-thickness wound samples. Sections were stained with Sirius red in picric acid and photographed under cross-polarized light. (a) Normal skin, day 0. (b) Day 7 post-injury; (c) day 14; (d) day 21; (e) day 28; (f) day 35; (g) day 42; (h) day 49; (i) day 56; (j) day 63; (k) day 70. Bar=250μm.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
RNA yield for backcross skin wounds. Mean±SEM, N=20. *P<0.05, **P<0.01 as compared to normal values.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

6. Figure 5
mRNA levels for extracellular matrix molecules, MMPs, and TIMPs during healing in backcross full-thickness wounds. Mean±SEM, N=20. (a) BMP-1, (b) decorin, (c) collagen I, (d) MMP 2, (e) HSP 47, (f) TIMP 2, (g) osteopontin, (h) TIMP 3. *P<0.05, **P<0.01 as compared to normal values.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

7. Figure 6
mRNA levels for cytokines, growth factors, and transcription factors during healing in backcross full-thickness wounds. Mean±SEM, N=20. (a) IL-1, (b) IGF-1, (c) IL-6, (d) KGF, (e) TNF-α, (f) TGF-β, (g) c-fos. *P<0.05, **P<0.01 as compared to normal values.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

8. Figure 7
Backcross litter-to-litter variability. Mean±SEM, litter 1, N=5; litter 2, N=2; litter 3, N=3; litter 4, N=3; litter 5, N=4; and litter 6, N=3. (a) osteopontin, (b) KGF. *P<0.05, **P<0.01 as compared to other litters. ‡P<0.01 as compared to day 42 and day 49 post-injury.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

9. Figure 8
Comparison of RT-PCR and real-time PCR methodologies for the assessment of mRNA expression patterns. Mean±SEM, N=6. (a) IGF-1, (b) TIMP 3. *P<0.05, **P<0.01 as compared to normal values within groups; †P<0.05, ‡P<0.01 between methodologies.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions