1. GRANULOCYTES ABO compatibility:
RBC’s may be grafted in the donor process, and these will react if not depleted or properly matched
Must be ABO matched
CMV status:
Always important to assess in any immune suppressed patient
Store at room temperature and give within 24hrs of collection:
Avoids unnecessary complications, saves time (granulocytes have a short life span)
Pre-med:
Hydrocortisone may be at the Consultant’s discretion, but Promethazine and Paracetamol (unless LFT’s ++) are always indicated
Medical and nursing supervision:
The RN (or above) never leaves the patient unattended during the infusion and medical assistance must be less than 30secs away. Observations pre & post infusion, hourly during infusion or more frequent if clinically indicated
Give over 1-2hrs:
Minimises reactions
No leucocytes filters:
To use a filter is to remove the very cells you’re trying to give- granulocytes are leucocytes
The matter of Amphotericin:
This drug is know for considerable reactivity and depletes platelets and granulocytes.