1. Representative protein structures for bacterial PPIases.
Representative protein structures for bacterial PPIases. Displayed are structures of the representative members of the three PPIase families of Escherichia coli. (A) PPIase domain of the FKBP FkpA (PDB entry 1Q6U) showing the characteristic α-helix wrapped by a five-stranded β-sheet. The space between the helix and the β-sheet forms the enzymatically active hydrophobic pocket. (B) PPIase domain of the cyclophilin PpiB (PDB entry 2NUL), consisting of the centrally located β-barrel flanked by one α-helix on each side. (C) PPIase domain of the parvulin Par10 (PDB entry 1JNT), organized in the form of a central antiparallel sheet of 4 β-strands with 4 α-helices surrounding it.
Can M. Ünal, and Michael Steinert Microbiol. Mol. Biol. Rev. 2014; doi: /MMBR