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Structure and receptor-binding properties of SCH-C.

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Presentation on theme: "Structure and receptor-binding properties of SCH-C."— Presentation transcript:

1 Structure and receptor-binding properties of SCH-C.
Structure and receptor-binding properties of SCH-C. (A) The structure of SCH-C. (B) SCH-C inhibits RANTES binding to CCR5. SCH-C was titrated over the concentration range indicated in the presence of [125I]RANTES, and the binding of RANTES to human CCR5 expressed on CHO-cell membranes was measured (■). (C) SCH-C binds with high affinity to CCR5. [3H]SCH-C was titrated over the concentration range indicated; the amount bound to human CCR5 on B550 cells was measured, and the Bmax and KD values were calculated from the Scatchard plot (Inset). The value of each assay point is an average of triplicates (●). Julie M. Strizki et al. PNAS 2001;98:22: ©2001 by National Academy of Sciences

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