1. Changes in c-Fos expression evoked by the gambling test under the standard or double-reward condition. c-Fos expression was analyzed immunohistochemically in saline- and METH-treated rats 2 h after the gambling test.
Changes in c-Fos expression evoked by the gambling test under the standard or double-reward condition. c-Fos expression was analyzed immunohistochemically in saline- and METH-treated rats 2 h after the gambling test. Photographs show typical examples of c-Fos expression in various brain areas of saline- or METH-treated rats, following the gambling test under the standard condition. Values are means ± SE (n = 3–4). *P < 0.05 vs. saline-treated group (standard condition). †P < 0.05 vs. saline-treated group (double-reward condition). #P < 0.05 vs. METH-treated group (double-reward condition). n.s., not significant. OFC, orbitofrontal cortex [F(3,9) = 5.65, P < 0.05]; INS, insular cortex [F(3,9) = 4.93, P < 0.05]; NAc, core of the nucleus accumbens [F(3,10) = 11.3, P < 0.05]; NAs, shell of the nucleus accumbens [F(3,10) = 1.74, P > 0.05]; St, striatum [F(3,10) = 8.25, P < 0.05]. (Scale bar: 100 µm.)‏
Hiroyuki Mizoguchi et al. PNAS 2015;112:29:E3930-E3939
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