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Aya Matsui, Veronica A. Alvarez  Neuron 

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1 Undercover Power of Endocannabinoids: Postsynaptic Ion-Channel Modulator 
Aya Matsui, Veronica A. Alvarez  Neuron  Volume 93, Issue 6, Pages (March 2017) DOI: /j.neuron Copyright © Terms and Conditions

2 Figure 1 Novel and Canonical Endocannabinoid Actions in Dopamine Neurons Endocannabinoid 2-AG is synthesized upon the activation of Gq protein-coupled receptors (GqPCR), such as metabotropic glutamate, orexin, and neurotensin receptors. Through its canonical actions, 2-AG serves as a retrograde signal to activate presynaptic CB1 receptors on excitatory and inhibitory synaptic terminals. Gantz and Bean (2017) show that novel postsynaptic actions of 2-AG on Kv4.3 channels inhibit A-type potassium currents and enhance the excitability of dopamine neurons. Neuron  , DOI: ( /j.neuron ) Copyright © Terms and Conditions

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