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Dynamic cardiomyoplasty: at the crossroads

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Presentation on theme: "Dynamic cardiomyoplasty: at the crossroads"— Presentation transcript:

1 Dynamic cardiomyoplasty: at the crossroads
Michael A. Acker, MD  The Annals of Thoracic Surgery  Volume 68, Issue 2, Pages (August 1999) DOI: /S (99)

2 Fig 1 Actuarial survival in Phase II multicenter clinical trial for dynamic cardiomyoplasty (DCMP): Comparison between patients having DCMP and matched reference group. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 Long-term effects of cardiomyoplasty on cardiac function as seen in pressure–volume relationship. Ventricular pressure–volume loops and relations are shown for each patient at baseline (before cardiomyoplasty) and 1 year after operation. All patients demonstrated a reduction in chamber volume. Vertical arrows show initial end-diastolic volume. (DPVR = diastolic pressure–volume relationship; ESPVR = end-systolic pressure–volume relationship.) (Reproduced from Kass and associates [21] by permission of the American Heart Association.) The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4 Fig 3 Design of Phase III randomized clinical trial, also known as C-SMART (Cardiomyoplasty–Skeletal Muscle Assist Randomized Trial). The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5 Fig 4 Dynamic cardiomyoplasty probably acts by at least two mechanisms to ultimately limit the remodeling process of progressive heart failure. The Annals of Thoracic Surgery  , DOI: ( /S (99) )


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