1. Prognostic significance of central venous-to-arterial carbon dioxide difference during the first 24 hours of septic shock in patients with and without impaired cardiac function 
G. Muller, E. Mercier, P. Vignon, M. Henry-Lagarrigue, T. Kamel, A. Desachy, V. Botoc, G. Plantefève, J.P. Frat, F. Bellec, J.P. Quenot, P.F. Dequin, T. Boulain 
British Journal of Anaesthesia 
Volume 119, Issue 2, Pages (August 2017)
DOI: /bja/aex131
Copyright © 2017 The Author(s) Terms and Conditions

2. Fig 1
CONSORT diagram.
British Journal of Anaesthesia  , DOI: ( /bja/aex131)
Copyright © 2017 The Author(s) Terms and Conditions

3. Fig 2
Time course of cv-art CO2 gap compared between patients with and without impaired cardiac function. Orange and blue squares represent arithmetic means of the cv-art CO2 gap in patients with (cardiac group) and without (non-cardiac group) impaired cardiac function (see text for definition), respectively. Bars extend from mean−1 standard error to mean+1 standard error. *Indicate a significant difference between the cardiac and non-cardiac groups at H0 (P=0.002), H6 (P=0.0005), and H12 (P=0.023).
British Journal of Anaesthesia  , DOI: ( /bja/aex131)
Copyright © 2017 The Author(s) Terms and Conditions

4. Fig 3
Time course of the cv-art CO2 gap in the cardiac and non-cardiac groups according to day 28 survival status. Left and right panels show the cv-art CO2 gap in the non-cardiac and cardiac group, respectively. Orange squares and blue squares represent the arithmetic mean of the cv-art CO2 gap in day 28 non-survivors and survivors, respectively. Bars represents 1 standard error. Orange and blue dashed lines and corresponding annotations indicate significant cv-art CO2 gap change over time in the Day 28 non survivors and Day 28 survivors group, respectively. Orange vertical dashed lines indicate at which time points the cv-art CO2 gap was significantly different between day 28 non-survivors and survivors.
British Journal of Anaesthesia  , DOI: ( /bja/aex131)
Copyright © 2017 The Author(s) Terms and Conditions

5. Fig 4
Survival curve according to a cv-art CO2 gap ≤0.9 or > 0.9 kPa at H12 in the cardiac group.
British Journal of Anaesthesia  , DOI: ( /bja/aex131)
Copyright © 2017 The Author(s) Terms and Conditions

6. Fig 5
Time course of blood lactate level according to day 28 survival status and cv-art CO2 gap in the cardiac group. *Indicate a significant difference (P<0.05) in the blood lactate level between survivors and non-survivors for a given time point. **Indicate a significant difference (P<0.05) in the blood lactate level between H0 and a given time point. Note that lactate showed a significant increase with time only in the subgroup of non-survivors in the cardiac group who showed a high cv-art CO2 gap at H12.
British Journal of Anaesthesia  , DOI: ( /bja/aex131)
Copyright © 2017 The Author(s) Terms and Conditions