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Albumin Regeneration for Extracorporeal Liver Support Using Prometheus: A Step in the Right Direction  Pamela Leckie, Nathan Davies, Rajiv Jalan  Gastroenterology 

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Presentation on theme: "Albumin Regeneration for Extracorporeal Liver Support Using Prometheus: A Step in the Right Direction  Pamela Leckie, Nathan Davies, Rajiv Jalan  Gastroenterology "— Presentation transcript:

1 Albumin Regeneration for Extracorporeal Liver Support Using Prometheus: A Step in the Right Direction  Pamela Leckie, Nathan Davies, Rajiv Jalan  Gastroenterology  Volume 142, Issue 4, Pages (April 2012) DOI: /j.gastro Copyright © 2012 AGA Institute Terms and Conditions

2 Figure 1 Molecular structure of albumin to illustrate its complexity and the different functional domains. The main functions are imparted by the Cys 34 component (orange shading), which provides thiol function and functions as an antioxidant, the metal binding domain (blue shading) which functions to scavenge the free, metal and the binding sites (BS; in yellow), which function to bind circulating protein-bound substances. ABiC, Albumin binding capacity; ACLF, acute-on-chronic liver failure; EPR, Electron paramagnetic spectroscopy; HMA:HNA, Human mercapt albumin/Human non-mercapt albumin ratio; IMAR, Ischemic modified albumin. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions


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