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Volume 57, Issue 6, Pages (June 2000)

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1 Volume 57, Issue 6, Pages 2299-2307 (June 2000)
Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1  Sophie Doublier, Danielle Seurin, Bruno Fouqueray, Marie-Christine Verpont, Patrice Callard, Liliane J. Striker, Gary E. Striker, Michel Binoux, Laurent Baud  Kidney International  Volume 57, Issue 6, Pages (June 2000) DOI: /j x Copyright © 2000 International Society of Nephrology Terms and Conditions

2 Figure 1 Light micrographs of a glomerulus from homozygous transgenic mice (A), heterozygous transgenic mice (B), and nontransgenic mice (C). All mice were three months old (PAS stain, final magnification ×400). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

3 Figure 2 Light micrographs of a glomerulus from homozygous transgenic mice (A) and nontransgenic mice (B). All mice were three months old. PAS-positive materials in the vascular pole are indicated by an arrow. Magnification is ×400. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

4 Figure 3 Immunochemistry micrographs of a glomerulus stained by mAb that was reactive with laminin (first column), type IV collagen (second column), or type I collagen (third column). (A, B, and C) Homozygous transgenic mice. (D, E, and F) Nontransgenic mice. All mice were three months old. Magnification is ×400. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

5 Figure 4 Electron microscopic photograph of a glomerulus from homozygous transgenic mice (A) and nontransgenic mice (B). All mice were three months old (×14,000). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

6 Figure 5 Plasma concentrations of GH in homozygous transgenic mice, heterozygous transgenic mice, and nontransgenic mice of three months of age. The baseline indicates the limit of sensitivity of the assay. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions


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