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Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities  Lili He, PhD, Nehal A.

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Presentation on theme: "Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities  Lili He, PhD, Nehal A."— Presentation transcript:

1 Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities  Lili He, PhD, Nehal A. Parikh, DO, MS  Pediatric Neurology  Volume 53, Issue 4, Pages (October 2015) DOI: /j.pediatrneurol Copyright © 2015 The Authors Terms and Conditions

2 Figure 1 Representative examples of detected diffuse white matter abnormalities using our automated segmentation method. Axial T2-weighted images in the centrum semiovale region (left column) with detected diffuse white matter abnormalities delineated in white (right column), display representative examples of no-mild (top panel), and moderate-severe diffuse white matter abnormalities (lower panel). Pediatric Neurology  , DOI: ( /j.pediatrneurol ) Copyright © 2015 The Authors Terms and Conditions

3 Figure 2 Resting-state networks identified in very preterm infants with (left column) and without (right column) moderate-severe diffuse white matter abnormalities using group probabilistic independent component analysis during natural sleep. (A) frontoparietal; (B) executive control; (C) motor; (D) somatosensory; (E) medial visual; (F) occipital visual; and (G) lateral visual. Pediatric Neurology  , DOI: ( /j.pediatrneurol ) Copyright © 2015 The Authors Terms and Conditions

4 Figure 3 The effect of moderate-severe diffuse white matter abnormalities (DWMA) on the functional connectivity in very preterm infants. Decreased functional connectivity strength was observed in the group with moderate-severe DWMA for the executive control and frontoparietal networks; functional connectivity strength was similar for infants with and without moderate-severe DWMA for the visual, motor, and somatosensory networks. (The color version of this figure is available in the online edition.) Pediatric Neurology  , DOI: ( /j.pediatrneurol ) Copyright © 2015 The Authors Terms and Conditions


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